Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
John P. Iredale(University of Southampton), R. Christopher Benyon(University of Southampton), J. Pickering(University of Southampton), M. McCullen(University of Southampton), Michael Northrop(University of Southampton), Susannah Pawley(University of Southampton), Christopher Hovell(University of Southampton), M J Arthur(University of Southampton)
Cited by 1,065Open Access
Abstract
Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery from liver fibrosis to determine the biological mechanisms mediating resolution.
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