Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney
E. Oosterwdk(Leiden University), D. J. Ruiter(Leiden University), Ph. J. Hoedemaeker(Leiden University), E. K. J. Pauwels(Leiden University), Udo Jonas(Leiden University), I. Zwartendijk(Leiden University), S. O. Warnaar(Leiden University)
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Abstract
This report describes a monoclonal antibody designated G 250, subclass IgGl, that recognizes an antigen preferentially expressed on cell membranes of renal-cell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs from that of other RCC-related antibodies described. Preliminary experiments show that this antibody can be used to visualize RCC xenografts in nude mice by immunoscintigraphy.
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