Abyssomicins, Inhibitors of the para-Aminobenzoic Acid Pathway Produced by the Marine Verrucosispora Strain AB-18-032
Julia Riedlinger(University of Tübingen), Andreas Reicke(University of Tübingen), Hans Zähner(University of Tübingen), Bernhard Krismer, Alan T. Bull(University of Kent), Luís A. Maldonado, Alan C. Ward, Michael Goodfellow, Bojan Bister(University of Tübingen), Daniel Bischoff(University of Tübingen), Roderich D. Süßmuth(University of Tübingen), Hans‐Peter Fiedler(University of Tübingen)
Cited by 293Open Access
Abstract
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.
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