E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
Heiko Müller(Pfizer (United States)), Adrian P. Bracken(European Institute of Oncology), Richard Vernell(European Institute of Oncology), Maria Cristina Moroni(European Institute of Oncology), Fred C. Christians(European Institute of Oncology), Emanuela Grassilli(European Institute of Oncology), Elena Prosperini(European Institute of Oncology), Elena Vigo(European Institute of Oncology), Jonathan D. Oliner(Amgen (United States)), Kristian Helin(European Institute of Oncology)
Cited by 752Open Access
Abstract
The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate development and cell proliferation in part by inhibiting the activity of E2F-regulated promoters. We have used high-density oligonucleotide arrays to identify genes in which expression changed in response to activation of E2F1, E2F2, and E2F3. We show that the E2Fs control the expression of several genes that are involved in cell proliferation. We also show that the E2Fs regulate a number of genes involved in apoptosis, differentiation, and development. These results provide possible genetic explanations to the variety of phenotypes observed as a consequence of a deregulated pRB/E2F pathway.
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