A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard(Merck & Co., Inc., Rahway, NJ, USA (United States)), Scott D. Feighner(Merck & Co., Inc., Rahway, NJ, USA (United States)), Doris Cully(Merck & Co., Inc., Rahway, NJ, USA (United States)), Joseph P. Arena(Merck & Co., Inc., Rahway, NJ, USA (United States)), Paul Liberator(Merck & Co., Inc., Rahway, NJ, USA (United States)), Charles Rosenblum(Merck & Co., Inc., Rahway, NJ, USA (United States)), Michel Hamelin(Merck & Co., Inc., Rahway, NJ, USA (United States)), Donna L. Hreniuk(Merck & Co., Inc., Rahway, NJ, USA (United States)), Oksana Palyha(Merck & Co., Inc., Rahway, NJ, USA (United States)), Jennifer Anderson(Merck & Co., Inc., Rahway, NJ, USA (United States)), Philip S. Paress(Merck & Co., Inc., Rahway, NJ, USA (United States)), Carmen Dı́az(Merck & Co., Inc., Rahway, NJ, USA (United States)), Michael F. Chou(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ken K. Liu(Merck & Co., Inc., Rahway, NJ, USA (United States)), Karen K. McKee(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sheng‐Shung Pong(Merck & Co., Inc., Rahway, NJ, USA (United States)), L Y Chaung(Merck & Co., Inc., Rahway, NJ, USA (United States)), Alex Elbrecht(Merck & Co., Inc., Rahway, NJ, USA (United States)), Mike Dashkevicz(Merck & Co., Inc., Rahway, NJ, USA (United States)), R.P. Heavens(Sightsavers), Mike Rigby(Sightsavers), D.J.S. Sirinathsinghji(Sightsavers), Dennis Dean(Merck & Co., Inc., Rahway, NJ, USA (United States)), David G. Melillo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Arthur A. Patchett(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ravi P. Nargund(Merck & Co., Inc., Rahway, NJ, USA (United States)), Patrick R. Griffin(Merck & Co., Inc., Rahway, NJ, USA (United States)), Julie A. DeMartino(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sunil Gupta(Merck & Co., Inc., Rahway, NJ, USA (United States)), James M. Schaeffer(Merck & Co., Inc., Rahway, NJ, USA (United States)), Roy G. Smith(Merck & Co., Inc., Rahway, NJ, USA (United States)), Lex H.T. Van der Ploeg(Merck & Co., Inc., Rahway, NJ, USA (United States))
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Abstract
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.
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