The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward(University of Pennsylvania), Jay Patel(Memorial Sloan Kettering Cancer Center), David R. Wise(University of Pennsylvania), Omar Abdel‐Wahab(Memorial Sloan Kettering Cancer Center), Bryson D. Bennett(Princeton University), Hilary A. Coller(Princeton University), Justin R. Cross(University of Pennsylvania), Valeria R. Fantin(Agios Pharmaceuticals (United States)), Cyrus V. Hedvat(Memorial Sloan Kettering Cancer Center), Alexander E. Perl(University of Pennsylvania), Joshua D. Rabinowitz(Princeton University), Martin Carroll(University of Pennsylvania), Shinsan M. Su(Agios Pharmaceuticals (United States)), Kim A. Sharp(University of Pennsylvania), Ross L. Levine(Memorial Sloan Kettering Cancer Center), Craig B. Thompson(University of Pennsylvania)
Cited by 1,981Open Access
Abstract
Related Papers
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis, Anthony Mancuso, Evgueni Daikhin et al.|Proceedings of the National Academy of Sciences|2007|2.6k