ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
E Eytan(Technion – Israel Institute of Technology), Avram Hershko(Rappaport Family Institute for Research in the Medical Sciences), T Armon(Technion – Israel Institute of Technology), D Ganoth(Technion – Israel Institute of Technology)
Cited by 370
Related Papers
THE UBIQUITIN SYSTEM
|Annual Review of Biochemistry|1998|8.8k
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
|Nature Cell Biology|1999|1.5k
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.
|Journal of Biological Chemistry|1983|1.1k
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
|Molecular Biology of the Cell|1995|755
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.
|Proceedings of the National Academy of Sciences|1980|746