Risk factors for incident dementia after stroke and transient ischemic attack

Jie Yang(Chinese University of Hong Kong), Adrian Wong(Education University of Hong Kong), Zhaolu Wang(Chinese University of Hong Kong), Wenyan Liu(Chinese University of Hong Kong), Lisa Au(Chinese University of Hong Kong), Yunyun Xiong(Nanjing General Hospital of Nanjing Military Command), Chiu‐Wing Winnie Chu(Chinese University of Hong Kong), Eric Yim Lung Leung(Hong Kong Sanatorium and Hospital), Sirong Chen(Hong Kong Sanatorium and Hospital), Christine Lau(Chinese University of Hong Kong), Anne Chan(Chinese University of Hong Kong), Alexander Yuk Lun Lau(Chinese University of Hong Kong), Florence Fan(Chinese University of Hong Kong), Vincent Ip(Chinese University of Hong Kong), Yannie Soo(Chinese University of Hong Kong), Thomas Leung(Chinese University of Hong Kong), Chi Lai Ho(Hong Kong Sanatorium and Hospital), Ka Sing Wong(Chinese University of Hong Kong), Vincent Mok(Chinese University of Hong Kong)
Alzheimer s & Dementia
March 3, 2014
10.1016/j.jalz.2014.01.003
Cited by 139

Abstract

BACKGROUND: We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). METHODS: We compared clinical and imaging features between patients with consecutive stroke/TIA with (n = 88) and without (n = 925) incident dementia at 3 to 6 months after a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those with (n = 37) and without (n = 13) incident dementia. RESULTS: Age, history of diabetes mellitus, severity of white matter changes (WMCs), and medial temporal lobe atrophy (MTLA) were associated with incident dementia. Alzheimer's disease (AD)--like PiB retention was found in 29.7% and 7.7% (P = .032) of patients with and without incident dementia, respectively. CONCLUSIONS: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment.

Related Papers

No related papers found

Powered by citation graph analysis