A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones
K. C. Nicolaou(University of Pennsylvania), G. SKOKOTAS(University of Pennsylvania), Peter E. Maligres(University of Pennsylvania), Guido Zuccarello(University of Pennsylvania), Edwin J. Schweiger(University of Pennsylvania), Kazunobu Toshima(University of Pennsylvania), Sebastian Wendeborn(University of Pennsylvania)
Cited by 79
Abstract
DNA-cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l–3 are examples. They are capable of cleaving ϕX174 DNA in a pH-dependent reaction with maximal activity at pH 8.5.
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