Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides
Jason J. Coull(Office of Infectious Diseases), Guocheng He(Office of Infectious Diseases), Christian Melander(California Institute of Technology), Victor C. Rucker(California Institute of Technology), Peter B. Dervan(California Institute of Technology), David M. Margolis(VA North Texas Health Care System)
Cited by 65Open Access
Abstract
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.
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