Overestimation of risk ratios by odds ratios in trials and cohort studies: alternatives to logistic regression
Mirjam J. Knol(University Medical Center Utrecht), Saskia le Cessie(Leiden University Medical Center), Ale Algra(Leiden University Medical Center), Jan P. Vandenbroucke(Leiden University Medical Center), Rolf H. H. Groenwold(University Medical Center Utrecht)
Cited by 487Open Access
Abstract
Logistic regression analysis, which estimates odds ratios, is often used to adjust for covariables in cohort studies and randomized controlled trials (RCTs) that study a dichotomous outcome. In case–control studies, the odds ratio is the appropriate effect estimate, and the odds ratio can
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