Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening
Raju Subramanian(Gilead Sciences (United States)), Chun Li(University of Southern California), G. Erich Wohlhieter(Amgen (United States)), Matthew P. Bourbeau(Amgen (United States)), Seifu Tadesse(Amgen (United States)), Matthew R. Lee(Amgen (United States)), Christopher Fotsch(Amgen (United States)), Guomin Yao(Amgen (United States)), Qingping Zeng(Amgen (United States)), Gary L. Skiles, Xianghong Wang(Chinese University of Hong Kong), Yihong Zhou(Soochow University), John G. Allen(Amgen (United States)), Sekhar Surapaneni(Bristol-Myers Squibb (United States)), Chester Yuan(Amgen (United States)), Fang‐Tsao Hong(Amgen (United States)), Xiaochun Zhu(Amgen (United States))
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