Uniform Rattle‐type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained‐Release Property
Wenru Zhao(East China University of Science and Technology), Hangrong Chen(Chinese Academy of Sciences), Yongsheng Li(East China University of Science and Technology), Liang Li(East China University of Science and Technology), Meidong Lang(East China University of Science and Technology), Jianlin Shi(East China University of Science and Technology)
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Abstract
Abstract A novel kind of rattle‐type hollow magnetic mesoporous sphere (HMMS) with Fe 3 O 4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol–gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H 2 reduction. Such a structure has the merits of both enhanced drug‐loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g −1 when ibuprofen is used as a model drug, and the IBU–HMMS system has a sustained‐release property, which follows a Fick's law.
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