Mutagenesis and Mapping of a Mouse Gene, <i>Clock</i> , Essential for Circadian Behavior
Martha Hotz Vitaterna(Northwestern University), David P. King(Northwestern University), Anne‐Marie Chang(Northwestern University), Jon M. Kornhauser(Northwestern University), Phillip L. Lowrey(Northwestern University), J. David McDonald(University of Wisconsin–Madison), William F. Dove(University of Wisconsin–Madison), Lawrence H. Pinto(Northwestern University), Fred W. Turek(Northwestern University), Joseph S. Takahashi
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Abstract
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.
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