The IGF‐1 receptor in cancer biology

Renato Baserga(Thomas Jefferson University), Francesca Peruzzi(Temple University), Krysztof Reiss(Temple University)
International Journal of Cancer
September 18, 2003
10.1002/ijc.11487
Cited by 644Open Access
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Abstract

The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.

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