High-level semi-synthetic production of the potent antimalarial artemisinin
Christopher J. Paddon(Amyris (United States)), Patrick J. Westfall(Amyris (United States)), Douglas J. Pitera(Amyris (United States)), Kirsten R. Benjamin(Amyris (United States)), Karl J. Fisher(Amyris (United States)), Derek McPhee(Amyris (United States)), Michael D. Leavell(Amyris (United States)), Anna Tai(Amyris (United States)), A. Denise Main(Amyris (United States)), Diana G. Eng(Amyris (United States)), Devin R. Polichuk(Saskatchewan Research Council (Canada)), Keat H. Teoh(Saskatchewan Research Council (Canada)), Darwin W. Reed(Saskatchewan Research Council (Canada)), T. Treynor(Amyris (United States)), Jacob R. Lenihan(Amyris (United States)), Hanxiao Jiang(Amyris (United States)), Martin Fleck(Amyris (United States)), Sunil Bajad(Amyris (United States)), G. Dang(Amyris (United States)), D. Dengrove(Amyris (United States)), Don Diola(Amyris (United States)), G. Dorin(Amyris (United States)), Kenneth W. Ellens(Saskatchewan Research Council (Canada)), Scott Fickes(Amyris (United States)), Jorge L. Galazzo(Amyris (United States)), Sara P. Gaucher(Amyris (United States)), T. Geistlinger(Amyris (United States)), Roselani I. Henry(Amyris (United States)), M. Hepp(Saskatchewan Research Council (Canada)), Tizita Horning(Amyris (United States)), Talat Iqbal(Amyris (United States)), Lance Kizer(Amyris (United States)), Bonny Lieu(Amyris (United States)), David J. Melis(Amyris (United States)), Nathan A. Moss(Amyris (United States)), Rika Regentin(Amyris (United States)), S. Secrest(Amyris (United States)), Hiroko Tsuruta(Amyris (United States)), Raúl Vázquez López(Amyris (United States)), Lars F. Westblade(Amyris (United States)), Lan Xu(Amyris (United States)), Min Yu(Amyris (United States)), Y. Zhang(Saskatchewan Research Council (Canada)), L. Zhao(Amyris (United States)), Jeff Lievense(Amyris (United States)), Patrick S. Covello(Saskatchewan Research Council (Canada)), Jay D. Keasling(Joint BioEnergy Institute), K. K. Reiling(Amyris (United States)), Neil S. Renninger(Amyris (United States)), Jonathan Newman(Amyris (United States))
Cited by 2,058Open Access
Abstract
Related Papers
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
Patrick J. Westfall, Douglas J. Pitera, Jacob R. Lenihan et al.|Proceedings of the National Academy of Sciences|2012|725