High-throughput screening of catalytically inactive mutants of protein tyrosine phosphatases (PTPs) in a phosphopeptide microarray
Hongyan Sun(National University of Singapore), Lay Pheng Tan(National University of Singapore), Liqian Gao(National University of Singapore), Shao Q. Yao(National University of Singapore)
Cited by 50
Abstract
We report herein a novel phosphopeptide microarray capable of noncovalently "trapping" catalytically inactive mutants of protein tyrosine phosphatases (PTPs), and its application in high-throughput determination of PTP substrate specificity.
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