Diversity of gene expression in adenocarcinoma of the lung
Mitchell Garber(Howard Hughes Medical Institute), Olga G. Troyanskaya(Howard Hughes Medical Institute), Karsten Schluens(Howard Hughes Medical Institute), Simone Petersen(Howard Hughes Medical Institute), Zsuzsanna Thaesler(Howard Hughes Medical Institute), Manuela Pacyna-Gengelbach(Howard Hughes Medical Institute), Matt van de Rijn(Howard Hughes Medical Institute), Glenn D. Rosen(Howard Hughes Medical Institute), Charles M. Perou(Howard Hughes Medical Institute), Richard I. Whyte(Howard Hughes Medical Institute), Russ B. Altman(Howard Hughes Medical Institute), Patrick O. Brown(Howard Hughes Medical Institute), David Botstein(Howard Hughes Medical Institute), Iver Petersen(Howard Hughes Medical Institute)
Cited by 1,302Open Access
Abstract
The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.
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