Radiation pneumonitis: A new approach to the derivation of time-dose factors

William M. Wara(University of California, San Francisco), Theodore L. Phillips(University of California, San Francisco), Lawrence W. Margolis(University of California, San Francisco), Vernon Smith(University of California, San Francisco)
Cancer
September 1, 1973
10.1002/1097-0142(197309)32:3<547::aid-cncr2820320306>3.0.co;2-4
Cited by 233Open Access
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Abstract

A series of 51 patients treated with 92 separate lung fields for metastatic pulmonary disease between 1958 and 1971 is reviewed. The treatment data are converted into nominal single doses (NSD) and a newly derived formula for estimated single doses (ED). The 5% incidence level of pneumonitis without dactinomycin is 770 rets (NSD) and 510 rets (ED) and with dactinomycin, 520 rets (NSD) and 450 rets (ED). A safe treatment regimen for avoiding radiation pneumonitis is 1500 rads in 10 fractions with dactinomycin and 2500 rads in 20 fractions without dactinomycin.

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