Use of monoclonal antibodies for the histopathological diagnosis of human malignancy
KC Gatter(John Radcliffe Hospital), Z. Abdulaziz(John Radcliffe Hospital), Peter C. L. Beverley(University College Hospital), J R Corvalán, C. H. J. Ford(Queen Elizabeth Hospital Birmingham), EB Lane(The Honourable Society of Lincoln's Inn), Mário Rogério Lima Mota(John Radcliffe Hospital), JRG Nash(John Radcliffe Hospital), Karen Pulford(John Radcliffe Hospital), H. Stein(Christian-Albrechts-Universität zu Kiel), Joyce Taylor‐Papadimitriou(The Honourable Society of Lincoln's Inn), C S Woodhouse(Queen Elizabeth Hospital Birmingham), DY Mason(John Radcliffe Hospital)
Cited by 222Open Access
Abstract
This paper describes the use of a panel of seven monoclonal antibodies (selected so as to include reagents reactive with both epithelial and lymphoid cells) for distinguishing between anaplastic carcinoma and high grade lymphoma. Details are given of the immunohistological reactions of these antibodies against a wide range of both normal and malignant tissues and of a number of practical instances in which use of the antibody panel enabled a diagnosis to be made when routine histological examination had been inconclusive.
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