Diurnal Variation of Plasma Brain‐Derived Neurotrophic Factor (BDNF) in Humans: An Analysis of Sex Differences

Armando Piccinni(University of Pisa), Donatella Marazziti(University of Pisa), Alessandro Del Debbio(University of Pisa), Carolina Bianchi(University of Pisa), Isabella Roncaglia(University of Pisa), Claudio Mannari(University of Pisa), Nicola Origlia(National Academies of Sciences, Engineering, and Medicine), Mario Catena Dell’Osso(University of Pisa), Gabriele Massimetti(University of Pisa), Luciano Domenici(University of L'Aquila), Liliana Dell’Osso(University of Pisa)
Chronobiology International
January 1, 2008
10.1080/07420520802387773
Cited by 131

Abstract

Scant information is available on the diurnal variation of peripheral neurotrophic factors, including brain-derived neurotrophic factor (BDNF), in human beings. We explored plasma and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both sexes. Statistically significant diurnal variation in plasma BDNF level was detected in men, with the peak at 08:00 h and nadir at 22:00 h. At this time, the plasma BDNF concentration of men was significantly lower than that of women (p=.02). However, no diurnal variation was found either in plasma BDNF of women, in either the follicular or luteal phases of the menstrual cycle, or in serum BDNF level in both men and women. These findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex-related.

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