A Putative ABC Transporter Confers Durable Resistance to Multiple Fungal Pathogens in Wheat

Simon G. Krattinger(Commonwealth Scientific and Industrial Research Organisation), Evans Lagudah(Commonwealth Scientific and Industrial Research Organisation), Wolfgang Spielmeyer(Commonwealth Scientific and Industrial Research Organisation), Ravi P. Singh(Commonwealth Scientific and Industrial Research Organisation), Julio Huerta‐Espino(Commonwealth Scientific and Industrial Research Organisation), Helen McFadden(Commonwealth Scientific and Industrial Research Organisation), Eligio Bossolini(Commonwealth Scientific and Industrial Research Organisation), Liselotte L. Selter(Commonwealth Scientific and Industrial Research Organisation), Beat Keller(Commonwealth Scientific and Industrial Research Organisation)
Science
February 19, 2009
10.1126/science.1166453
Cited by 1,455

Abstract

Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.

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