Isolation and characterization of variant IGF‐1 as well as IGF‐2 from adult human brain
Christine Carlsson‐Skwirut(Karolinska Institutet), Hans Jörnvall(Karolinska Institutet), Arne Holmgren(Karolinska Institutet), Charlotte Andersson(Karolinska Institutet), Tomas Bergman(Karolinska Institutet), Gunilla Lundquist(Karolinska Institutet), Barbro Sjögren(Karolinska Institutet), Vicki R. Sara(Karolinska Institutet)
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Abstract
The forms of somatomedin present in the adult human brain have been characterized in this study. Two peptides were purified by acidification, size exclusion chromatography, affinity chromatography, FPLC and HPLC. Structural analysis identified these peptides as the variant form of IGF-1 with a truncated N-terminal region earlier isolated from human fetal brain and IGF-2. The presence of the truncated IGF-1 variant and IGF-2 in the human CNS suggests their role as neuropeptides.
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