Identification of an Amplified, Highly Expressed Gene in a Human Glioma
Kenneth W. Kinzler(Johns Hopkins University), Sandra H. Bigner(Duke Medical Center), Darell D. Bigner(Duke Medical Center), Jeffrey M. Trent(University of Arizona), M L Law(Roosevelt Institute), Stephen J. O’Brien(National Cancer Institute), Albert J. Wong(Johns Hopkins University), Bert Vogelstein(Johns Hopkins University)
Cited by 679
Abstract
A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.
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