Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

Lilly Bourguignon(University of California, San Francisco), Eli Gilad(San Francisco VA Medical Center)
Journal of Biological Chemistry
July 25, 2009
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