The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes

Christian Grønhøj(Frederick National Laboratory for Cancer Research), Arthur O. Anderson(United States Army Medical Research Institute of Infectious Diseases), Ettore Appella(National Cancer Institute), Joost J. Oppenheim(Frederick National Laboratory for Cancer Research), Kouji Matsushima(Frederick National Laboratory for Cancer Research)
Science
March 17, 1989
10.1126/science.2648569
Cited by 1,047

Abstract

T lymphocyte chemotactic factor (TCF) was purified to homogeneity from the conditioned media of phytohemagglutinin-stimulated human blood mononuclear leukocytes by a sequence of chromatography procedures. The amino-terminal amino acid sequence of the purified TCF showed identity with neutrophil-activating protein (NAP-1). Both TCF and recombinant NAP-1 (rNAP-1) were chemotactic for neutrophils and T lymphocytes in vitro supporting the identity of TCF with NAP-1. Injection of rNAP-1 into lymphatic drainage areas of lymph nodes in Fisher rats caused accelerated emigration of only lymphocytes in high endothelial venules. Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes.

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