Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
Katsuhiko Yamasaki(The University of Osaka), Tetsuya Taga(The University of Osaka), Yuuichi Hirata(The University of Osaka), Hideo Yawata(The University of Osaka), Yoshikazu Kawanishi(The University of Osaka), Brian Seed(Massachusetts General Hospital), Tadatsugu Taniguchi(The University of Osaka), Toshio Hirano(The University of Osaka), Tadamitsu Kishimoto(The University of Osaka)
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Abstract
Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
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