Simian Sarcoma Virus <i>onc</i> Gene, v- <i>sis</i> , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor
Russell F. Doolittle(University of California San Diego), Michael W. Hunkapiller(California Institute of Technology), Leroy Hood(California Institute of Technology), Sushilkumar G. Devare(National Cancer Institute), Keith C. Robbins(National Cancer Institute), Stuart A. Aaronson(National Cancer Institute), Harry N. Antoniades(Harvard University)
Cited by 1,549
Abstract
The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.
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