HDACs and Hypertrophy, Kinases and Cancer

Abstract

I n the course of daily life, the heart reacts to alterations in workload demand with changes in contractility and beating rate; over time, robust changes in ventricular volume and mass take place. In the context of pathological triggers, however, cardiac remodeling is ultimately maladaptive and a discrete milestone in disease pathogenesis. The end result is heart failure, a syndrome with 50% 5-year mortality, rivaling the most lethal cancers.