Tolerance and Chimerism after Renal and Hematopoietic-Cell Transplantation
John D. Scandling(Stanford University), Stéphan Busque(Stanford University), Sussan Dejbakhsh‐Jones(Stanford University), Claudia Benike(Stanford University), Maria T. Millan(Stanford University), Judith A. Shizuru(Stanford University), Richard T. Hoppe(Stanford University), Robert Lowsky(Stanford University), Edgar G. Engleman(Stanford University), Samuel Strober(Stanford University)
Cited by 502Open Access
Abstract
We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed chimerism, and the function of the kidney allograft has been normal for more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease.
Related Papers
No related papers found
Powered by citation graph analysis