Biodegradable therapeutic MOFs for the delivery of bioactive molecules
Stuart Miller(Institut Lavoisier de Versailles), Daniela Heurtaux(Institut Lavoisier de Versailles), Tarek Baâti(Centre National de la Recherche Scientifique), Patricia Horcajada(Institut Lavoisier de Versailles), Jean−Marc Grenèche(Le Mans Université), Christian Serre(Centre National de la Recherche Scientifique)
Cited by 298
Abstract
A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.
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