Common Virulence Factors for Bacterial Pathogenicity in Plants and Animals
Laurence G. Rahme(Harvard University), Emily J. Stevens(Burn Institute), Sean F. Wolfort(Massachusetts General Hospital), Jing Shao(Harvard University), Ronald G. Tompkins(Massachusetts General Hospital), Frederick M. Ausubel(Harvard University)
Cited by 1,378
Abstract
A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for Arabidopsis, causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied P. aeruginosa strains. Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals.
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