A Highly Specific BODIPY-Based Fluorescent Probe for the Detection of Hypochlorous Acid

Zhen-Ning Sun(University of Hong Kong), Fengqin Liu(University of Hong Kong), Yan Chen(University of Hong Kong), Paul Kwong Hang Tam(University of Hong Kong), Dan Yang(University of Hong Kong)
Organic Letters
May 1, 2008
10.1021/ol800507m
Cited by 335

Abstract

A fluorescent probe, HKOCl-1, has been successfully developed for the detection of hypochlorous acid on the basis of a specific reaction with p-methoxyphenol. The formation of HOCl has been successfully detected not only in an abiotic system but also in an enzymatic system (myeloperoxidase/H2O2/Cl(-) system) and in living macrophage cells upon stimulation. This new probe might be used as an efficient tool for probing the roles HOCl plays in biological systems.

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