Synthesis of Functionalized Oxazolines and Oxazoles with DAST and Deoxo-Fluor

Andrew J. Phillips(University of Pittsburgh), Yoshikazu Uto(Indiana University Bloomington), Peter Wipf(Indiana University Bloomington), Michael J. Reno(University of Pittsburgh), David R. Williams(University of Pittsburgh)
Organic Letters
March 25, 2000
Cited by 461

Abstract

[formula: see text] A mild and highly efficient cyclization of beta-hydroxy amides to oxazolines is described using DAST and Deoxo-Fluor reagents. A one-pot protocol for the synthesis of oxazoles from beta-hydroxy amides is also presented.


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