Inhibitory Effect of Dauricine on Inflammatory Process Following Focal Cerebral Ischemia/Reperfusion in Rats

Xiaoyan Yang(Huazhong University of Science and Technology), Shiqin Jiang(Huazhong University of Science and Technology), Li Zhang(Huazhong University of Science and Technology), Qiangni Liu(Huazhong University of Science and Technology), Gong Pei-li(Huazhong University of Science and Technology)
The American Journal of Chinese Medicine
January 1, 2007
10.1142/s0192415x07004990
Cited by 45

Abstract

Our previous experimental studies showed that dauricine could protect the brain from ischemic damage, but the underlying mechanisms were unknown. In this study, we investigated the effect of dauricine on the changes of the inflammation process induced by ischemia/reperfusion (I/R). After I/R, the enzyme activity of MPO, the expression of ICAM-1 and the transcription of IL-1beta and TNF-alpha mRNA were all significantly increased (p < 0.01). And after treatment with dauricine, they were all significantly reduced compared to the vehicle-treated I/R group (p < 0.05 or p < 0.01). These results suggest that dauricin attenuates the inflammation process induced by I/R. The neuroprotective effect of dauricine may partly due to the inhibition acute inflammation induced by I/R.

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