Imaging Dopamine Receptors in the Human Brain by Positron Tomography
Henry N. Wagner(Johns Hopkins University), H. Donald Burns(Johns Hopkins University), Robert F. Dannals(Johns Hopkins University), Dean F. Wong(Johns Hopkins University), Bengt Långström(Uppsala University), Timothy Duelfer(Johns Hopkins University), J. James Frost(Johns Hopkins University), Hayden T. Ravert(Johns Hopkins University), Jonathan M. Links(Johns Hopkins University), Shelley B. Rosenbloom(Johns Hopkins University), Scott E. Lukas(National Institutes of Health), Alfred V. Kramer(Johns Hopkins University), Michael J. Kuhar(Johns Hopkins University)
Cited by 742
Abstract
Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.
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