Dopamine as A Robust Anchor to Immobilize Functional Molecules on the Iron Oxide Shell of Magnetic Nanoparticles
Chenjie Xu(Hong Kong University of Science and Technology), Keming Xu(Hong Kong University of Science and Technology), Hongwei Gu(Hong Kong University of Science and Technology), Rongkun Zheng(Hong Kong University of Science and Technology), Hui Liu(Hong Kong University of Science and Technology), Xixiang Zhang(Hong Kong University of Science and Technology), Zhihong Guo(Hong Kong University of Science and Technology), Bing Xu(Hong Kong University of Science and Technology)
Cited by 875
Abstract
We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.
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