Stress-Induced Suppression of Immunity in Adrenalectomized Rats
Steven E. Keller(City University of New York), Jay M. Weiss(Rockefeller University), Steven J. Schleifer(City University of New York), N. E. Miller(Rockefeller University), Marvin Stein(City University of New York)
Cited by 389
Abstract
Stress-induced suppression of lymphocyte stimulation by phytohemagglutinin was demonstrated in Isolated lymphocytes and in cultures of whole blood from adrenalectomized rats. The results demonstrate that corticosteroid independent mechanisms participate in the suppression of lymphocyte function by stressors. Stress-induced lymphopenia, however, was found to be adrenal dependent, indicating that the modulation of immunity by stress is complex and multidetermined.
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