Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base-Free Conditions

Chao Mei(Dalian Institute of Chemical Physics), Zhaoqing Xu(Dalian Institute of Chemical Physics), Fei Huang(Dalian Institute of Chemical Physics), Zhengkun Yu(Dalian Institute of Chemical Physics), Yanfeng Gao(Zhengzhou University)
The Journal of Organic Chemistry
April 17, 2012
Cited by 179

Abstract

A Lewis acid (Ag(I), Ni(II), or Fe(II)) catalyzed, Cu(II)-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers.


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