ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS
Judah Folkman(Boston Children's Hospital), Ezio Merler(Boston Children's Hospital), Charles M. Abernathy(Boston Children's Hospital), Gretchen M. Williams(Boston Children's Hospital)
Cited by 1,663Open Access
Abstract
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.