Functional and clinical aspects of the myelomonocyte protein calprotectin.

Abstract

Calprotectin is a calcium binding heterocomplex protein consisting of two heavy and one light chain.' 2 It belongs to the S-100 protein family and is derived predominantly from neu- trophils and monocytes.' This protein is distributed in myelomonocytic cells, epithelial cells, and keratinocytes and in various tissues and fluids in the body,' and is a putative protective protein.3 Calprotectin and its subunits appear to have regulatory functions in the inflammatory process,5 6 and various bio- on August 18, 2023 by guest.