Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity
Dokyoung Kim(Pohang University of Science and Technology), Sunderraman Sambasivan(Pohang University of Science and Technology), Hyoseok Nam(Pohang University of Science and Technology), Ki Hean Kim(Pohang University of Science and Technology), Jin Young Kim(Pohang University of Science and Technology), Taiha Joo(Pohang University of Science and Technology), Kyung‐Ha Lee(Pohang University of Science and Technology), Kyong‐Tai Kim(Pohang University of Science and Technology), Kyo Han Ahn(Pohang University of Science and Technology)
Cited by 102
Abstract
Reaction-based fluorescent probes for monoamine oxidases A and B are developed based on a new two-photon absorbing compound and its precursor. The probes show turn-on fluorescence response to the enzymes owing to the two-photon absorbing compound produced by the enzymatic activity, as monitored by one- as well as two-photon microscopy for the first time.
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