Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy
Liming Wang(National Center for Nanoscience and Technology), Ying Liu(National Center for Nanoscience and Technology), Wei Li(Institute of High Energy Physics), Xiumei Jiang(Center for NanoScience), Yinglu Ji(Center for NanoScience), Xiaochun Wu(National Center for Nanoscience and Technology), Ligeng Xu(National Center for Nanoscience and Technology), Yang Qiu(National Center for Nanoscience and Technology), Kai Zhao(Chinese Academy of Sciences), Taotao Wei(Chinese Academy of Sciences), Yufeng Li(Institute of High Energy Physics), Yuliang Zhao(Houston Methodist), Chunying Chen(Institute of High Energy Physics)
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Abstract
We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy.
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