Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes
Motonari Kondo(Tohoku University), Toshikazu Takeshita(Tohoku University), Masaya Higuchi(Tohoku University), Masataka Nakamura(Tohoku University), Tetsuo Sudo(Toray (United States)), Shin-lchi Nishikawa(Kyoto University), Kazuo Sugamura(Tohoku University)
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Abstract
The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.
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