Targeting Epigenetic Readers in Cancer

Mark A. Dawson(National Health Service), Tony Kouzarides(Wellcome/Cancer Research UK Gurdon Institute), Brian J.P. Huntly(Medical Research Council)
New England Journal of Medicine
August 15, 2012
Cited by 395

Abstract

Much of gene expression is regulated by chromatin, which allows or blocks transcription. Alterations in chromatin that influence gene expression in certain cancers can be affected by drugs. Clinical testing is eagerly awaited.


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