Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors
Mark Mercola(University of California, Los Angeles), Joan Goverman(University of California, Los Angeles), Carol J. Mirell(University of California, Los Angeles), Kathryn Calame(University of California, Los Angeles)
Cited by 259
Abstract
Enhancer sequences are regulatory regions that greatly increase transcription of certain eukaryotic genes. An immunoglobulin heavy-chain variable gene segment is moved from a region lacking enhancer activity to a position adjacent to the known heavy-chain enhancer early in B-cell maturation. In lymphoid cells, the heavy-chain and SV40 enhancers bind a common factor essential for enhancer function. In contrast, fibroblast cells contain a functionally distinct factor that is used by the SV40 but not by the heavy-chain enhancer. The existence of different factors in these cells may explain the previously described lymphoid cell specificity of the heavy-chain enhancer.
Related Papers
No related papers found
Powered by citation graph analysis