Cell‐Responsive Synthetic Hydrogels
Marco Lütolf(University of Zurich), G. P. Raeber(University of Zurich), Andreas H. Zisch(University of Zurich), Nicola Tirelli(University of Zurich), Jeffrey A. Hubbell
Cited by 519Open Access
Abstract
Synthetic biomaterial matrices have been formed in the presence of cells by a Michael‐type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell‐surface proteases, allowing cells to create paths for 3D cell migration (see Figure).
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