Macromolecular Crowding Meets Tissue Engineering by Self‐Assembly: A Paradigm Shift in Regenerative Medicine

Abhigyan Satyam(Ollscoil na Gaillimhe – University of Galway), Pramod Kumar(Ollscoil na Gaillimhe – University of Galway), Xingliang Fan(Ollscoil na Gaillimhe – University of Galway), Alexander Gorelov(University College Dublin), Yury Rochev(Ollscoil na Gaillimhe – University of Galway), Lokesh Joshi(Ollscoil na Gaillimhe – University of Galway), Héctor Peinado(Cornell University), David Lyden(Cornell University), B.W.J. Thomas(University of Oxford), Brian J. Rodriguez(University College Dublin), Michael Raghunath(National University of Singapore), Abhay Pandit(Ollscoil na Gaillimhe – University of Galway), Dimitrios I. Zeugolis(Ollscoil na Gaillimhe – University of Galway)
Advanced Materials
February 6, 2014
10.1002/adma.201304428
Cited by 179Open Access
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Abstract

MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.

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