A Multifunctional Cytokine (IL-6/BSF-2) and Its Receptor

T Hirano(The University of Osaka), Tetsuya Taga(The University of Osaka), Katsuhiko Yamasaki(The University of Osaka), Tadashi Matsuda(The University of Osaka), Bo Tang(The University of Osaka), Atsushi Muraguchi(The University of Osaka), Yasuhiro Horii(The University of Osaka), Sachiko Suematsu(The University of Osaka), Yuuichi Hirata(The University of Osaka), Hideo Yawata(The University of Osaka), Masatoshi Shimizu(The University of Osaka), Michiaki Kawano(The University of Osaka), Tadamitsu Kishimoto
International Archives of Allergy and Applied Immunology
August 5, 2009
10.1159/000234743
Cited by 33

Abstract

Interleukin 6 (IL-6)/B cell stimulatory factor 2 is a multifunctional cytokine produced by both lymphoid and nonlymphoid cells. IL-6 regulates immune response, acute phase reaction, and hematopoiesis. It was found that IL-6 production by T cells is dependent on macrophages, and IL-6 is one of essential factors for pokeweed mitogen induced immunoglobulin production. Both high- and low-affinity IL-6 receptors were identified. The molecular cloning of IL-6 receptors demonstrated that this receptor is a member of the immunoglobulin superfamily. The deregulated production of IL-6 is suggested to be involved in the pathogenesis of autoimmune diseases and in the development of multiple myeloma.

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