Galanin — a novel biologically active peptide from porcine intestine
Kazuhiko Tatemoto(Karolinska Institutet), Åke Rökaeus(Karolinska Institutet), Hans Jörnvall(Karolinska Institutet), Thomas J. McDonald(Western University), Viktor Mutt(Karolinska Institutet)
Cited by 1,492Open Access
Abstract
The isolation of a novel biologically active peptide, designated galanin, is described. The peptide was discovered by the detection of its C-terminal amide structure in porcine intestinal extract using a chemical method. It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His -Arg-Ser -Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. Galanin was found to contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.